ABSTRACT: To report a rare case of erythema multiforme (EM) associated with methotrexate (MTX) with cutaneous and oral manifestations and to compare it to existing cases in which MTX was not used for cancer treatment. A 56-years- old female, in physical examination skin lesions and multiple oral ulcers associated with pain during manipulation were observed, and underwent treatment for rheumatoid arthritis with Methotrexate 2.5mg. During examination patient-reported that 15 days ago she had undergone a rheumatoid factor examination, doubling the MTX dosage (10mg / day) without doctor's consent. The diagnostic hypothesis of EM. The medical conduct consisted of the suspension of MTX and prescription of a vitamin complex with folinic acid. Local dental therapy for to control oral lesions, pain control and lip hydration was performed using low-level laser therapy (Twin Laser, P: 40mW, T: 50s, DE: 50J / cm), benzydamine hydrochloride spray, purified lanolin for lip dryness, and toothpaste without sodium lauryl sulfate to prevent burning. After 12 days, there was significant remission of oral and skin signs and symptoms, which confirmed the diagnosis was EM due to MTX intoxication. Thorough clinical evaluation and anamnesis favored diagnosis and early multi-professional management provided remission of oral and skin lesions, prevented systemic complications.

RESUMEN: El objetivo de este trabajo fue informar un caso raro de eritema multiforme (EM) asociado a metotrexato (MTX) con manifestaciones cutáneas y orales y compararlo con casos existentes en los que no se utilizó MTX para el tratamiento del cáncer. Caso clínico: Mujer de 56 años, en el examen físico se observaron lesiones cutáneas y múltiples úlceras de la cavidad oral asociadas a dolor durante la manipulación.Se sometió a tratamiento para la artritis reumatoide con metotrexato 2,5 mg. Durante el examen, la paciente informó que hacía 15 días se había sometido a un examen de factor reumatoide, duplicando la dosis de MTX (10 mg / día) sin el consentimiento del médico. La hipótesis diagnóstica de EM. La conducta médica consistió en la suspensión de MTX y prescripción de un complejo vitamínico con ácido folínico. La terapia dental local para el control de las lesiones orales, el control del dolor y la hidratación de los labios se realizó mediante terapia con láser de bajo nivel (Twin Laser, P: 40mW, T: 50s, DE: 50J / cm), aerosol de clorhidrato de bencidamina, lanolina purificada para la sequedad de labios y pasta de dientes sin lauril sulfato de sodio para evitar quemaduras. Después de 12 días, hubo una remisión significativa de los signos y síntomas orales y cutáneos, lo que confirmó el diagnóstico de ME por intoxicación por MTX. La evaluación clínica exhaustiva y la anamnesis favorecieron el diagnóstico y el manejo multiprofesional precoz proporcionó la remisión de las lesiones orales y cutáneas, evitando además complicaciones sistémicas.

Resumo Soluções bacterianas têm sido estudadas para promover a autocura de matrizes cimentícias, entretanto, a concentração dessas soluções variou entre os estudos. Consequentemente, o objetivo deste estudo foi avaliar o potencial de autocura de diferentes concentrações de Bacillus subtilis AP91 encapsulado em perlita expandida (PE). O exame visual e a absorção capilar de água foram medidos ao longo do tempo. As amostras de teste também foram submetidas a testes de resistência de força. Foram avaliadas as propriedades físico-químicas do EP e sua distribuição na matriz. Não houve tendência observada no efeito da concentração da solução na largura da fissura cicatrizada. No entanto, a concentração afetou a quantidade e o comprimento das fissuras cicatrizadas. A absorção capilar diminuiu conforme as fissuras foram curadas, enquanto nenhuma mudança significativa foi medida na resistência da força, independentemente da concentração. Os resultados indicaram que a EP proporcionou encapsulamento adequado à solução bacteriana e que há uma distribuição adequada das cápsulas na matriz cimentícia.

Abstract Bacterial solutions have been studied to promote self-healing of cementitious matrices, however, the concentration of this solutions varied between studies. Consequently, the objective of this study was to evaluate the self-healing potential of different concentrations of Bacillus subtilis AP91 encapsulated in expanded perlite (EP). Visual examination and capillary absorption of water was measured over time. Test samples were also subjected to strength resistance tests. The physiochemical properties of EP and his distribution on the matrix was evaluated. There was no observable trend in the effect of solution concentration on the width of crack healed. However, concentration affected the quantity and length of the fissures healed. Capillary absorption decreased as fissures were healed while no significant changes were measured in strength resistance regardless of the concentration. Results indicated that EP provided suitable encapsulation to the bacterial solution and there is an adequate distribution of the capsules in the cementitious matrix.

RESUMO A estrutura de controle de grandes empresas interfere na competição de mercado, bem como em sua estabilidade financeira. Estudos internacionais pesquisaram a rede de controle de empresas em seus países, outros expandiram tal visão para empresas transnacionais, realizando uma análise em nível mundial, ambas visando descrever a disposição dos principais controladores em uma estrutura de rede. Assim, o objetivo principal deste trabalho consiste em elaborar e analisar a rede de participação acionária em empresas listadas na B3 no ano de 2018. Trata-se de uma pesquisa descritiva com uso da técnica de Redes e dados obtidos no Economatica. Como resultado, foi observada uma rede com uma componente gigante composta por 726 atores, e uma rede de acionistas com baixa densidade, alta modularidade e com atores centrais de grande influência. Os resultados contribuem para a compreensão da atual estrutura da participação no mercado acionário brasileiro e espera-se que possa incentivar novas investigações sobre o mercado financeiro brasileiro.

ABSTRACT The shareholding structure of large companies interferes with market competition, as well as the financial stability thereof. Some international studies have analyzed the control network of companies in their corresponding countries, others have broadened such vision to transnational companies, conducting a world level analysis, with both aiming to describe the willingness of the main shareholders regarding the network structure. Thus, the challenge herein is to elaborate and analyze the network of shareholding in companies listed on B3 in 2018. This paper will be descriptive research that uses Network Analysis of data obtained from Economatica software. As a result, we find a network with a giant component comprised of 726 players and a shareholders’ network of low density, high modularity and with main players of high influence. The results contribute to understanding the current structure of the Brazilian stock market share and are expected to encourage new researches on the Brazilian financial market.

Resumo Este trabalho analisa se o Brasil está passando por um processo de secularização, utilizando dados da Pesquisa sobre Religião no Brasil, conduzida em 2007. Modelos de escolha discreta foram estimados para entender quais atributos dos indivíduos afetam a desfiliação, descrença e ausência de prática religiosa, para confirmar ou refutar as hipóteses do secularismo. A estimação confirmou algumas hipóteses da teoria. Por exemplo, ter uma opinião liberal acerca de assuntos morais e sociais está positivamente associado com secularismo, enquanto níveis mais baixos de renda incorrem em menores chances de desfiliação. Além disso, o perfil dos desfiliados, descrentes e não praticantes é semelhante. Portanto, é possível afirmar que existe secularização no Brasil.

Abstract This paper analyzes whether Brazil is experiencing a religious secularization process using data from Brazil Religion Survey conducted in 2007. Models of discrete choice are estimated to understand which individual attributes affect disaffiliation, disbelief and lack of religious practice, therefore confirming or disproving secularism hypotheses. Estimations confirm some hypotheses of the theory, for example, that having liberal opinions concerning moral and social issues is positively associated with secularism, and that lower income levels result in lower chances of disaffiliation. In addition, the profile of non-religious people, non-believers and those who do not practice religion is similar. Therefore, it is possible to affirm that there is secularization in Brazil.

Resumen Este trabajo analiza si Brasil está pasando por un proceso de secularización, para lo cual utiliza datos de la Investigación sobre Religión en Brasil, desarrollada en 2007. Modelos de elección discreta fueron estimados para entender qué atributos de los individuos afectan la desafiliación, la incredulidad y la ausencia de prácticas religiosas, para confirmar o refutar las hipótesis del secularismo. La estimación confirmó algunas hipótesis de la teoría. Por ejemplo, tener una opinión liberal acerca de asuntos morales y sociales está positivamente asociado con el secularismo, mientras que ingresos más bajos implican menores posibilidades de desafiliación. Además, el perfil de los desafiliados, no creyentes y no practicantes es similar. Por lo tanto, es posible afirmar que existe secularización en Brasil.

BACKGROUND Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.

RESUMO O crescimento populacional aliado ao consumo elevado tem aumentado consideravelmente a geração de resíduos sólidos. Diversos são os impactos negativos gerados pela destinação incorreta desses rejeitos. Logo, a utilização de resíduos é cada vez mais atraente tanto no âmbito econômico quanto no ambiental. Neste sentido, no presente trabalho é demonstrada a produção de espumas vítreas, com baixo impacto ambiental, utilizando como matéria-prima resíduos de vidro de lâmpadas fluorescentes e casca de ovo vermelho como agente espumante. Os agentes precursores tiveram as suas composições químicas, estruturas cristalinas e granulometrias elucidadas através das técnicas de fluorescência de raios X, difração de raios X e análise de dispersão a laser, respectivamente. A análise termogravimétrica foi utilizada para avaliar a perda de massa da casca de ovo vermelha durante o aquecimento. As espumas vítreas foram formuladas com 7% em massa de agentes espumantes, conformadas por prensagem uniaxial e queimados entre 650 °C e 850 °C, com taxa de aquecimento de 2,5 °C/min. A influência da temperatura de queima na expansão, na densidade e na porosidade dos corpos cerâmicos obtidos foi avaliada. As espumas tiveram a suas expansões volumétricas avaliadas, sendo suas microestruturas caracterizadas por microscopia óptica. Os resultados mostraram a produção de espumas vítreas altamente porosas, com alta expansão, entre de 122 a 266%, e com baixa densidade, variando de 0,37 a 0,65 g.cm−3, sendo que os melhores resultados foram alcançados a 750 °C. O material obtido possui grande potencial para aplicações na indústria civil, como isolante térmico e acústico, além de minimizar os impactos ambientais causados pelo descarte indevido de lâmpadas fluorescentes e dos resíduos da casca de ovos.

ABSTRACT Population growth coupled with high consumption has considerably increased the generation of solid waste. Several are the negative impacts generated by the incorrect destination of these wastes. Therefore, the use of waste is becoming attractive both in economic and in environmental terms. In this sense, the present work demonstrates the production of foam glass with low environmental impact, using as raw material glass residues of fluorescent lamps and red eggshell as a foaming agent. The precursor agents had their chemical compositions, crystal structures and granulometry elucidated by X-ray fluorescence, X-ray diffraction, and laser scattering analysis techniques, respectively. The thermogravimetric analysis was used to evaluate the loss of mass of the red eggshell during the heating. The foam glass was formulated with 7 wt% of foaming agents, shaped by uniaxial pressing and burned between 650 °C and 850 °C at a heating rate of 2.5 ° C/min. The influence of firing temperature in the expansion, density, and porosity of the ceramic cups obtained was evaluated. The foam glasses have their volumetric expansions evaluated, and their microstructures were characterized by light microscopy. The results showed the production of foam glass highly porous glassy with high expansion between 122-266%, and low-density ranging from 0.37 to 0.65 g.cm−3, and the best results were achieved at 750 °C. The material obtained has great potential for applications in the civil industry, such as thermal and acoustic insulation, as well as the decrease of environmental impacts caused by the undue discharge of fluorescent lamps and egg shell residues.

OBJECTIVES: The removal of pre-malignant colorectal lesions prevents cancer. Hyoscine has been proposed as a means of improving diagnosis by reducing colonic movements. The aim of this study was to analyze whether this anti-spasmodic enhances the detection of pre-malignant colorectal lesions. METHODS: In a randomized, double-blinded fashion patients received hyoscine or a saline solution in all consecutive colonoscopies in which the cecum was reached. Lesions were analysed with respect to number, size, location, histology and capillary pattern. RESULTS: A total of 440 colonoscopies were randomized. The overall polyp detection rate (PDR) and the adenoma detection rate (ADR) were 65.2% and 49.3%, respectively. In the hyoscine group, non-polypoid lesions were detected significantly more often (p=0.01). In the placebo group 281 lesions were diagnosed (202 adenomas) and in the hyoscine group 282 lesions were detected (189 adenomas) (p=0.23). The PDR and ADR were similar between the placebo and hyoscine groups (64% vs 66% and 50% vs 47%, respectively). No differences were observed between the two groups in the advanced-ADR or advanced neoplasia detection rate, as well the mean numbers of polyps, adenomas, advanced adenomas and advanced neoplasias detected per patient. The administration of hyoscine also did not improve the diagnostic accuracy of digital chromoendoscopy. The presence of adenomatous polyps in the right colon was detected significantly more frequently in the hyoscine group (OR 5.41 95% CI 2.7 - 11; p<0.01 vs OR 2.3 95% CI 1.1 - 4.6; p=0.02). CONCLUSION: The use of hyoscine before beginning the withdrawal of the colonoscope does not seem to enhance the PDR and the ADR.

RESUMO Objetivo Analisar a influência da ligadura da tributária da veia porta no estímulo regenerativo hepático por meio de critérios imuno-histoquímicos. Métodos Dez suínos, divididos em dois grupos de cinco animais, foram submetidos à hepatectomia em dois estágios, sendo que os grupos foram diferenciados pela ligadura ou não da tributária da veia porta, responsável pela vascularização dos lobos lateral e medial esquerdos do fígado do suíno. Cinco dias após o procedimento, os animais foram reabordados para retirada de amostras hepáticas para posterior análise de histológica e imunoistoquímica com o marcador Ki67. Resultados O grupo submetido à hepatectomia com ligadura vascular apresentou incremento de 4% aproximadamente de hepatócitos em processo de regeneração, bem como grande número de células de Kupffer e células inflamatórias, quando comparado ao controle. Conclusão Em virtude da análise positiva da replicação celular observada por meio do marcador Ki67, pode-se observar que a ligadura de uma tributária da veia porta promoveu um maior estímulo de regeneração hepática, efeito observado com menor intensidade no grupo submetido apenas à ressecção hepática.

ABSTRACT Objective To analyze the influence of portal vein ligation in hepatic regeneration by immunohistochemical criteria. Methods Ten pigs divided into two groups of five animals underwent hepatectomy in two stages, and the groups were differentiated by ligation or not of the left portal vein tributary, which is responsible for vascularization of the left lateral and medial lobes of the pig liver. Five days after the procedure, the animals underwent liver biopsies for further analysis of histological and immunohistochemical with marker Ki67. Results The group submitted to hepatectomy with vascular ligation showed an increase of approximately 4% of hepatocytes in regeneration status, as well as a greater presence of Kupffer and inflammatory cells as compared to control. Conclusion As a result of positive cell replication observed through the Ki67 marker, we can suspect that the ligation of a tributary of the portal vein associated with liver resection promoted a greater stimulus of liver regeneration when compared to liver resection alone.

ABSTRACT PURPOSE: To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS: Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed for 30, 50, 70 and 90 days. Were analyzed the following parameters: foreign body reaction, granulation tissue, presence of myofibroblasts, neoangiogenesis, presence of synovial metaplasia, capsular thickness, total area and collagen percentage of type I and III, in capsules formed around silicone implants in both groups. RESULTS: The foreign body reaction was only present in the four polyurethane subgroups. The formation of granulation tissue and the presence of myofibroblasts were higher in the four polyurethane subgroups. Regarding to neoangiogenesis and synovial metaplasia, there was no statistical difference between the groups. Polyurethane group presented (all subgroups) a greater capsule thickness, a smaller total area and collagen percentage of type I and a higher percentage area of type III, with statistical difference. CONCLUSION: The use of polyurethane-coated implants should be stimulated by the long-term results in a more stable capsule and a lower incidence of capsular contracture, despite developing a more intense and delayed inflammatory reaction in relation to implants with textured surface.

O artigo busca compilar dados variados sobre a história de Angola, desde sua condição de colônia portuguesa, a partir do século 15, até o momento presente, para contextualizar a história do desenvolvimento da imprensa naquele território. Surgida no século 19, como consequência de uma decisão do governo colonial que, até então sempre interditara tal iniciativa, a imprensa se concretizou a partir de um boletim oficial que logo abriu caminho para publicações ditas independentes. Se a primeira geração de jornalistas em Angola era constituída de homens europeus brancos, funcionários públicos deslocados para a colônia ou exilados politicamente, a segunda geração já é formada por homens naturais de Angola, o que possibilita as primeiras manifestações independentistas. A síntese histórica que pretendemos encerra-se com a imposição da ditadura salazarista. Ela parte de levantamentos feitos no acervo da Biblioteca Pública Municipal do Porto e de pesquisa bibliográfica. O que se evidencia é que, embora hoje em dia devidamente preparada para enfrentar os desafios tecnológicos, a mídia angolana ainda enfrenta aquele que foi sempre seu maior desafio: a censura.

This article makes a review of different studies about the Angola's history, since the 15th. century, till the present moment, to contextualize the development of the country and of the press in this territory. The Angolean press begun in 19th. century, after a decision of the Portuguese government - it begins like an official bulletin, but this bulletin open the doors to the free press. If the first generation of journalists are composed by European and white peoples, political exiled or envoyed to the colony, like public officers, the second generation is constituted by native men, which produce the first examples of independentists thoughs. The synthesis of this experience ended with the salazarian dictatorship. The study is developed on the Porto´s Public Library and a specialized bibliography. The conclusion after the study is that even the Angolean midia has a very modern degree of technology suffer the old problem of his entire life: the censureship.

El articulo hace una compilación de estudios variados sobre la historia de Angola, desde su condición de colonia portuguesa, después del siglo 15, hasta el momento presente, para contextualizar la historia del desarrollo de la prensas en este territorio. Empezada en el siglo 19, como consecuencia de una decisión del gobierno colonial que, hasta entonces, siempre interditara tal iniciativa, la prensa angolana se ha concretizado a partir de una publicación oficial que ha abierto los caminos para las publicaciones independientes. Si la primera generación de periodistas en Angola era formada por europeos blancos, funcionarios públicos enviados a la colonia o exiliados políticos, la segunda generación es ya constituida por nativos de Angola, lo que posibilita las primeras manifestaciones de la independencia. La síntesis histórica que se intenta se termina con la imposición de la dictadura salazarista. El estudio ha sido desarrollado a partir del acervo de la Biblioteca Pública Municipal do Porto y la lectura de una bibliografía especializada. Aunque la media angolana de hoy experimente un grande desarrollo tecnológico enfrenta aún el desafío más duro desde siempre: la censura.